一、个人简介
石遵计，湖北大冶人，博士
电子邮件：shizj@lzu.edu.cn
通讯地址：甘肃省兰州市城关区天水南路222号兰州大学微生物研究中心
研究领域：利用微生物组、代谢组、转录组等多组学技术和分子生物学方法在微生物、代谢物与宿主互作领域开展系统性研究。以第一或通讯作者在《Journal of Agricultural and Food Chemistry》、《Environmental Microbiology》、《Chemical Engineering Journal》、《Integrative Zoology》、《Journal of Hazardous Materials》、《mSystems》、《Chemosphere》、《Ecotoxicology and Environmental Safety》、《Environmental Pollution》等国际主流期刊发表SCI论文多篇。
二、教育和科研经历
2021.05-至今：兰州大学，草地农业科技学院/草地微生物研究中心，研究员
2018.10-2020.11：中科院精密测量科学与技术创新研究院/华南理工大学，微生物学，联合培养博士后，合作导师：张利民研究员，国内著名代谢组学专家/曾新安教授，国内著名食品微生物专家
2015.07-2018.08：华中师范大学，微生物学，博士后，合作导师：谢波教授微生物学专家
2009.09-2015.06：华中农业大学农业微生物国家重点实验室，微生物学，博士，导师：王革娇教授国内著名环境微生物学专家
2012.12-2014.12：美国蒙大拿州立大学代谢组学和蛋白质组学研究中心，微生物学，国家公派联合培养博士生，导师：Timothy R. McDermott国际著名微生物学专家/ Brian Bothner国际著名代谢组学专家
2005.09-2009.06：石河子大学(211工程)，生物科学，学士
三、获奖情况与学术兼职
1. 2009年获校级优秀毕业生
2. 2012年获国家公派留美联合培养博士生资格
3. 2017年指导学生获得第一届全国大学生生命科学竞赛国家三等奖
4. 2018年指导学生获得第三届全国生命科学创新创业大赛国家三等奖
5. 2019年-至今，环境科学1区Top期刊Chem Eng J (影响因子13.4)审稿人
6. 2021年--至今，中巴生物质能源国家联合实验室学术委员会委员，Land Degradation & Development (影响因子3.6)审稿人，Frontiers Cellular and Infection Microbiology (影响因子5.7)审稿人
7. 2022年--至今，中国草原出版专家库第一期成员，担任中国微生物学学会会员兼任甘肃省微生物学学会理事，担任Frontiers in Microbiology(影响因子4)编委和客座主编，担任Frontiers in Plant Science(影响因子4.1)审稿人，草业科学和草业学报审稿人
8. 2023年--至今，中国草学会会员，担任农林科学1区Top期刊Journal of Agricultural and Food Chemistry(影响因子5.7)审稿人，担任Plant and Soil(影响因子3.9)审稿人，担任Clinica Chimica Acta(影响因子3.2)审稿人，担任Antimicrobial Resistance and Infection Control(影响因子4.8)审稿人，担任Frontiers sustainable food systems(影响因子3.7)审稿人
9. 2023年--至今，获2023年度和2024年度“周集中草地微生物科研奖励基金”二等奖。
10. 2025年--至今，微生物学领域顶刊iMeta (影响因子23.8，中科院1区Top)青年编委。
四、承担科研项目
1. 甘肃省科技重大专项-农业领域(24ZD13NA016)，典型退化草地近自然修复技术集成于示范，2024.12-2027.12，课题骨干。
2. 国家重点研发计划项“农业生物种质资源挖掘与创新利用”重点专项“草种基因资源挖掘与种质创新利用”(2023YFD1200300)，优质新种质创制与利用，2023.12-2028.11，子课题负责人。
3. 国家自然科学基金区域创新发展联合基金，重点支持项目(U23A200206)，白花草木樨香豆素形成机理与品质提升研究，2024.01.01-2027.12.31，课题负责人。
4. 省部共建农产品质量安全危害因子与风险防控国家重点实验室开放课题(2021DG700024-KF202426)，饲草新品种营养评价及其微生物过程研究，2024.01-2025.12，主持。
5. 青海省“帅才科学家负责制”项目(2023-NK-147)，草种创新及其在草地农业系统中的作用，2023.01-2027.12，子课题负责人。
6. 甘肃省自然科学基金面上项目(22JR5RA457)，镉胁迫条件下根际细菌WS2对歪头菜根际微生物的影响及与歪头菜互作抗镉的研究，2022.10-2024.09，主持。
7. 中央高校学科交叉创新团队建设项目(lzujbky-2022-ct04)，土草畜一体化健康微生态机制与调控团队，2022.07-2025.06，参与。
8. 广西遗传病精准医学重点实验室开放基金(GXWCH-ZDKF-2022-15)，遗传性疾病-阿斯伯格综合征基于全谱plus代谢组的精准诊断技术研发，2022.12-2025.11，主持。
9. 横向课题(071100008)，肠道微生物组数据分析，2023.05-2024.05，主持。
10. 横向课题(071100003)，土壤微生物组数据分析，2022.04-2023.04，主持。
11. 兰州大学人才引进科研启动基金，2021.05-2026.05，主持。
12. 广东省佛山市博士后启动基金，脂肪肝防治黄酮类化合物的研发及其平台建立， 2018.10-2020.10，主持。
13. 第67批中国博士后科学基金面上基金(2019M662893)，基于代谢研究细菌WN4与集胞藻互作抗镉的分子机制，2019.09-2021.09，主持。
14. 第58批中国博士后科学基金面上基金(2015M582247)，高通量测序和代谢组学分析水华中的细菌种类和菌藻互作，2015.11-2017-08，主持。
15. 湖北省自然科学基金项目(2017CFB164)，高抗镉细菌促进东南景天对镉吸收的研究，2017.01-2018.12，主持。
16. 广东省佛山市核心技术攻关项目(1920001000262)，基于药效物质基础研究的中药炮制标准化与中药开发，2019.10-2022.10，第六参与人。
五、发表论文
第一作者或通讯作者（*通讯作者）：
1. Na Shou; Christopher Rensing; Qiwen Lin; Wenqian Xu; Keyi Fu; Xuefeng Yuan; Dandan Wu; Fan Wang; Yanzhong Li;Zunji Shi*; Acesulfame potassium induces hepatic inflammation and fatty acids accumulation via disturbance of carnitine metabolism and gut microbiota. Food Bioscience, 2024, 62: 105101.(影响因子4.8, 1区Top,通讯作者)
2. Keyi Fu; Na Shou; Xuefeng Yuan; Wenqian Xu; Dandan Wu; Qi Wang; Lijun Gu; Yanjun Zeng; Yanzhong Li; andZunji Shi*; Impaired indole acetic acid and reduced indole-producing bacteria contribute to swainsonine-induced liver inflammation. Journal of agricultural and food chemistry, 2024, 72: 14078-14086.(影响因子5.7, 1区Top,通讯作者)
3. Keyi Fu; Christopher L. Schardl; Daniel Cook; Xuanli Cao; Ning ling; Chunyu He; Dandan Wu; Longhai Xue;Yanzhong Li*;andZunji Shi*; Multi-omics reveals mechanisms of Alternaria oxytropis inhibiting pathogenic fungi inOxytropis ochrocephala. Journal of agricultural and food chemistry, 2024, 72: 2397-2409.(影响因子5.7, 1区Top,通讯作者)
4. Keyi Fu; Xi Chen; Na Shou; Zilong Wang; Xuefeng Yuan; Dandan Wu; Qi Wang; Yanfen Cheng; Ning ling;Zunji Shi*; Swainsonine induces liver inflammation in mice via disturbance of gut microbiota and bile acid metabolism. Journal of agricultural and food chemistry, 2023,71: 1758−1767.(影响因子5.7, 1区Top,通讯作者)
5. Xi Chen†; Zaiwei Wang†; Junhu Su; Huan Li; Jinbo Xiong; Keyi Fu; Zilong Wang; Xuefeng Yuan; Ziyue Shi; Xiumei Miao; Mei Yang; Yunfeng Yang;Zunji Shi*; Altitude-dependent Metabolite Biomarkers Reveal the Mechanism of Plateau Pika Adaptation to High Altitudes. Integrative Zoology, 2023, 0: 1–15.(影响因子3.3, 1区,通讯作者)
6. Xiaoli Qi†; Keyi Fu†; Mingyuan Yue; Na Shou; Xuefeng Yuan; Xi Chen; Chunyu He; Yunfeng Yang*; andZunji Shi*; Kynurenic acid mediates bacteria-algae consortium in resisting environmental cadmium toxicity. Journal of Hazardous Materials, 2023, 444:130397.(影响因子12.2, 1区Top,通讯作者)
7. Zunji Shi; Ce Zhang; Hehua Lei; Chuan Chen; Zheng Cao; Yuchen Song; Gui Chen; Fang Wu; Jinlin Zhou; Yujing Lu; Limin Zhang; Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism. Journal of agricultural and food chemistry, 2022,70: 14732−14743.(影响因子5.7, 1区Top,第一作者)
8. Zunji Shi; Xiaoli Qi; Xin-an Zeng; Yujing Lu; Jinlin Zhou; Kehui Cui; Limin Zhang; A newly isolated bacterium Comamonas sp. XL8 alleviates the toxicity of cadmium exposure in rice seedlings by accumulating cadmium. Journal of Hazardous Materials, 2021, 403: 123824.(影响因子12.2, 1区Top,第一作者)
9. Zunji Shi; Gui Chen; Zheng Cao; Fang Wu; Hehua Lei; Chuan Chen; Yuchen Song; Caixiang Liu; Jinquan Li; Jinlin Zhou; Yujing Lu; Limin Zhang; Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease, Journal of agricultural and food chemistry. 2021, 69: 3982-3991.(影响因子5.7, 1区Top,第一作者)
10. Zunji Shi; Wenjuan Shen; Kai Yang; Ningning Zheng; Xiaofang Jiang; Limin Liu; Dandan Yang; Lizhi Zhang; Zhihui Ai* and Bo Xie*; Hexavalent chromium removal by a new composite system of dissimilatory iron reduction bacteriaAeromonas hydrophilaand nanoscale zero-valent iron. Chemical Engineering Journal, 2019, 362: 63-70.(影响因子13.4, 1区Top期刊，第一作者)
11. Ce Zhang†;Zunji Shi†; Hehua Lei; Fang Wu; Chuan Chen; Zheng Cao; Yuchen Song; Cui Zhang; Jinlin Zhou; Yujing Lu; and Limin Zhang*;Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling.Journal of agricultural and food chemistry, 2023,71, 7723−7733.(影响因子5.7, 1区Top,并列一作)
12. Ling Lei†; Dazhi Deng†; Wenqian Xu; Mingyuan Yue; Dandan Wu; Keyi Fu*;Zunji Shi*; Increased intestinal permeability and lipopolysaccharide contribute to swainsonine-induced systemic inflammation. Ecotoxicology and Environmental Safety, 2024, 284: 116912.(影响因子6.2, 2区Top,通讯作者)
13. Xuefeng Yuan†; Dandan Wu†; Dingguo Zhang; Chunyu He; Zilong Wang; Wenqian Xu; Na Shou; Keyi Fu; Mingyuan Yue; Xin Zhang;Zunji Shi*; Combining microbiome and pseudotargeted metabolomics revealed the alleviative mechanism ofCupriavidussp. WS2 on the cadmium toxicity inVicia unijuga A.Br. Environmental Pollution, 2024, 342: 123040.(影响因子7.6, 2区Top,通讯作者)
14. Yuchen Tan; Baohui Yao; Yukun Kang; Shangli Shi;Zunji Shi*; Junhu Su*；Emerging role of the crosstalk between gut microbiota and liver metabolome of subterranean herbivores in response to toxic plants. Ecotoxicology and Environmental Safety, 2024, 269: 115902.(影响因子6.2, 2区Top,通讯作者)
15. Hehua Lei; Yuchen Song; Manyuan Dong; Gui Chen; Zheng Cao; Fang Wu; Chuan Chen; Ce Zhang; Caixiang Liu;Zunji Shi*; and Limin Zhang*. Metabolomics Safety Assessments of Microcystin Exposure via Drinking Water in Rats. Ecotoxicology and Environmental Safety, 2021, 212: 111989.(影响因子6.2, 2区Top,并列通讯)
16. Zunji Shi; Zhengfeng Zhang; Meng Yuan; Song Wang; Mei Yang; Qi Yao; Wanni Ba; Jin Zhao; Bo Xie; Characterization of a high cadmium accumulating soil bacterium, Cupriavidus sp. WS2. Chemosphere, 2020, 247: 125834.(影响因子8.1, 2区Top,第一作者)
17. Jinbo Xiong*;Zunji Shi*; Editorial: Environments-pathogens-the gut microbiota and host diseases. Frontiers in Microbiology, 2024, 14:1357125.(影响因子4, 2区Top,通讯作者)
18. Dandan Wu; Qiwen Lin; Senao Hou; Xiaorui Cui; Na Shou; Xuefeng Yuan; Wenqian Xu; Keyi Fu; Qi Wang;Zunji Shi*; Gut microbiota and its metabolite taurine-β-muricholic acid
contribute to antimony or/and copper-induced liver inflammation. International Journal of Molecular Sciences, 2025, 3489014.(影响因子4.9, 2区,通讯作者)
19. Ling Lei †; Xuefeng Yuan†; Keyi Fu; Yuan Chen; Yijun Lu; Na Shou; Dandan Wu; Xi Chen; Jian Shi; Minjuan Zhang; Zhe Chen*; andZunji Shi*; Pseudotargeted metabolomics revealed the adaptive mechanism of Draba oreades Schrenk at high altitude. Frontiers in Plant Science, 2022, 13:1052640.(影响因子4.1, 2区,通讯作者)
20. Fang Li†; Xi Chen†; Bo Yang; Yingjie Guang; Dandan Wu;Zunji Shi*and Yanzhong Li*; Transcriptome Analysis Revealed the Molecular Response Mechanism of High-Resistant and Low-Resistant Alfalfa Varieties to Verticillium Wilt. Frontiers in Plant Science, 2022, 13:931001.(影响因子4.1, 2区,并列通讯)
21. Hu Liu; Tao Ran; Chengfu Zhang; Wenzhu Yang; Xiukun Wu; Allan Degen; Ruijun Long;Zunji Shi*and Jianwei Zhou*; Comparison of rumen bacterial communities between yaks (Bos grunniens) and Qaidam cattle (Bos taurus) fed a low protein diet with different energy levels. Frontiers in Microbiology, 2022, 13:982338.(影响因子4, 2区,并列通讯)
22. Jinbo Xiong* andZunji Shi*; Editorial: Environments-pathogens-the gut microbiota and host diseases. Frontiers in Microbiology, 2024, 14:1357125.(影响因子4, 2区,并列通讯)
23. Zunji Shi…, Xing Yang…,Xijuan Shi,Dajun Zhang,DengshuaiZhao,Yu Hao,JinkeYang,Xintian Bie,Wenqian Yan, Guohui Chen, Lingling Chen, XiangtaoLiu, HaixueZheng*andKeshanZhang*.Identification and verification of the role of key metabolites and metabolic pathways on ASFV replication based on serum pseudotargeted metabolomics. iScience, 27: 109345.(影响因子4.6, 2区,第一作者)
24. Zunji Shi; Hehua Lei; Gui Chen; Peihong Yuan; Zheng Cao; Hooi-Leng Ser; Xuehang Zhu; Fang Wu; Caixiang Liu; Manyuan Dong; Yuchen Song; Yangyang Guo; Chuan Chen; Kexin Hu; Yifan Zhu; Xin-an Zeng; Jinlin Zhou; Yujing Lu; Andrew D. Patterson; Limin Zhang; Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. mSystems, 2021, 6(1): e00985-20.(影响因子5, 2区,第一作者，主编精选文章)
25. Monika Tokmina-Lukaszewska†;Zunji Shi†; Brian Tripet; Timothy R McDermott; Valérie Copié; Brian Bothner*; Gejiao Wang*; Metabolic response ofAgrobacterium tumefaciens5A to arsenite. Environmental Microbiology, 2017, 19(2): 710-721.(影响因子4.3, 2区,并列一作, highlight paper)
26. Kaijian Sun; Xin Zhang; Xin Li; Xifeng Li; Shixing Su; Yunhao Luo; Hao Tian; Meiqin Zeng; Cheng Wang; Yugu Xie; Nan Zhang; Ying Cao; Zhaohua Zhu; Qianlin Ni; Wenchao Liu; Fangbo Xia; Xuying He;Zunji Shi*; Chuanzhi Duan*; Haitao Sun*; Plasma metabolic signatures for intracranial aneurysm and its rupture identified by pseudotargeted metabolomics. Clinica Chimica Acta, 2022, 538:36-45.(影响因子3.2, 3区,并列通讯)
27. Zunji Shi; Zhan Cao; Dong Qin; Wentao Zhu; Qian Wang; Mingshun Li; Gejiao Wang*; Correlation models between environmental factors and bacterial resistance to antimony and copper. PLoS ONE, 2013, 8(10): e78533.(影响因子, 3区,第一作者)
28. Zunji Shi;Guosheng Luo; Gejiao Wang*;Cellulomonas carbonissp. nov., isolated from coal mine soil.Int J Syst Evol Microbiol, 2012, 62:2004-2010.(影响因子2.8, 4区,第一作者)
29. 石遵计，曹政，胡科鑫，彭鑫碧，朱一帆，谢波*.镉离子污染条件下微生物群落中细菌与藻类的相互作用.微生物学报, 2019, 59(6): 1156-1163.(权威期刊CSCD,第一作者)
其他作者：
30. Fang Wu;Zunji Shi; Hehua Lei; Gui Chen; Peihong Yuan; Zheng Cao; Chuan Chen; Xuehang Zhu; Caixiang Liu; Manyuan Dong; Yuchen Song; Yangyang Guo; Jinlin Zhou; Yujing Lu; Limin Zhang*; Short-Term Intake of Hesperetin-7‑O‑Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice.Journal of Agricultural and Food Chemistry, 2021, 69: 1478-1486.(影响因子6.1, 1区Top,第二作者)
31. Gang Wu; Leixin Ge; Na Zhao; Fei Liu;Zunji Shi; Ningning Zheng; Dan Zhou; Xingpeng Jiang; Larry Halverson; Bo Xie*;Environment dependent microbial co-occurrences across a cyanobacterial bloom in a freshwater lake.Environmental Microbiology, 2021, 23(1):327-339.(影响因子5.1, 2区,第五作者)
32. Manyuan Dong; Peihong Yuan; Yuchen Song; Hehua Lei; Gui Chen; Xuehang Zhu; Fang Wu; Chuan Chen; Caixiang Liu;Zunji Shi; Limin Zhang*;In vitroeffects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte. Journal of Hazardous Materials, 2020, 399:122829.(影响因子13.6, 1区Top,第十作者)
33. Rachel A Rawle; Monika Tokmina-Lukaszewska;Zunji Shi; Yoon-Suk Kang; Brian P Tripet; Fang Dang; Gejiao Wang; Timothy R McDermott; Valerie Copie*; Brian Bothner*; Metabolic Responses to Arsenite Exposure Regulated through Histidine Kinases PhoR and AioS inAgrobacterium tumefaciens5A. Microorganisms, 2020, 8:1339.(影响因子4.5, 3区,第三作者)
34. Yoon-Suk Kang;Zunji Shi; Brian Bothner; Gejiao Wang; Timothy R McDermott*; Involvement of the Acr3 and DctA anti-porters in arsenite oxidation in Agrobacterium tumefaciens 5A.Environmental Microbiology,2014, 17(6):1950-1962.(影响因子5.1, 2区,第二作者)
35. Fang Chen,Zunji Shi, Gejiao Wang*;Arenimonas metallisp. nov., isolated from iron mine. Int J Syst Evol Microbiol, 2012, 62:1744-1749.(影响因子2.8, 3区,第二作者)
36. Guosheng Luo;Zunji Shi; Gejiao Wang*;Lysobacter arsenitoxydanssp. nov., an arsenite- oxidizing bacterium isolated from iron mining soil. Int J Syst Evol Microbiol, 2012, 62:1659-1665.(影响因子2.8, 3区,第二作者)
37. Guosheng Luo;Zunji Shi;Hui Wang;Gejiao Wang*.Skermanella stibiiresistenssp. nov., a highly antimony-resistant bacterium isolated from coal mining soil, and emended description of the genus ofSkermanella.Int J Syst Evol Microbiol, 2012, 62:1271-1276.(影响因子2.8, 3区,第二作者)
38. Liqiong Li; Hongliang Liu;Zunji Shi; Gejiao Wang*;Sphingobium cupriresistenssp. nov., a copper-resistant bacterium isolated from copper mine soil, and emended description of the genusSphingobium.Int J Syst Evol Microbiol, 2013, 63(Pt 2): 604-9.(影响因子2.8, 3区,第三作者)
六、学生培养
1. 2024年度国家自然科学基金青年学生基础研究项目（博士研究生），付可轶。
2. 2024年度王栋奖学金、2024年度国家奖学金，付可轶。
3. 草种创新与草地农业生态系统全国重点实验室第七届“研究生学术十杰”获二等奖（总排名第3），付可轶。
4. 兰州大学草地农业科技学院第16届研究生学术年会优秀论文一等奖（总排名第1），付可轶。
5. 2023年度研究生类“周集中草地微生物奖学金”，付可轶。
6. 中国草学会2024南京年会研究生论坛博士生组三等奖，付可轶。
7. 中央高校基本科研业务费优秀研究生项目，受娜。
8. 兰州大学草地农业科技学院第17届研究生学术年会优秀论文二等奖（总排名第2），受娜。
9. 兰州大学草地农业科技学院优秀研究生称号，袁学凤和付可轶。
10. 2024年度研究生类“周集中草地微生物奖学金”，袁学凤。
11. 兰州大学2022年国家级创新创业项目并顺利结项，何春雨。
12. 兰州大学2024年国家级创新创业项目并顺利结项，李想。
欢迎草学、微生物学、畜牧学、植物保护、生物信息学等相关专业背景的学生报考研究生，同时欢迎本科生参加科研训练或毕业设计，热烈欢迎热爱科研的有志青年加入！
